No evidence that GATA3 rs570613 SNP modifies breast cancer risk

SE Johnatty; FJ Couch; Z Fredericksen; R Tarrell; AB Spurdle; J Beesley; X Chen; D Gschwantler-Kaulich; CF Singer; C Fuerhauser; A Fink-Retter; SM Domchek; KL Nathanson; VS Pankratz; NM Lindor; AK Godwin; MA Caligo; J Hopper; MC Southey; GG Giles; C Justenhoven; H Brauch; U Hamann; YD Ko; T Heikkinen; K Aaltonen; K Aittomäki; C Blomqvist; H Nevanlinna; P Hall; K Czene; J Liu; S Peock; M Cook; R Platte; D Gareth Evans; F Lalloo; R Eeles; G Pichert; D Eccles; R Davidson; T Cole; J Cook; F Douglas; C Chu; S Hodgson; J Paterson; FBL Hogervorst; MA Rookus; C Seynaeve; J Wijnen; M Vreeswijk; M Ligtenberg; RB Van Der Luijt; TAM Van Os; HJP Gille; MJ Blok; C Issacs; MK Humphreys; L McGuffog; S Healey; O Sinilnikova; AC Antoniou; DF Easton; G Chenevix-Trench

Journal article

No evidence that GATA3 rs570613 SNP modifies breast cancer risk

SE Johnatty, FJ Couch, Z Fredericksen, R Tarrell, AB Spurdle, J Beesley, X Chen, D Gschwantler-Kaulich, CF Singer, C Fuerhauser, A Fink-Retter, SM Domchek, KL Nathanson, VS Pankratz, NM Lindor, AK Godwin, MA Caligo, J Hopper, MC Southey, GG Giles Show all

Breast Cancer Research and Treatment | SPRINGER | Published : 2009

DOI: 10.1007/s10549-008-0257-1

Abstract

GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility project and in pooled analysis of two case-control studies from Norway and Poland (P trend = 0.004), with some evidence for a stronger association with estrogen receptor (ER) negative tumours [Garcia-Closas M et al. (2007) Cancer Epidemiol Biomarkers Prev 16:2269-2275]. We genotyped GATA3 rs570613 ..

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University of Melbourne Researchers

Melissa Southey Author

Graham Giles Author

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Funding Acknowledgements

We wish to thank Claudine Isaacs for the samples from Georgetown; Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (funded by NHMRC grants 145684, 288704 and 454508) for their contributions to this resourcekConFab; the AOCS Management Group (D. Bowtell, G. Chenevix-Trench, A. deFazio, D. Gertig, A. Green, P. Webb), all the clinical and scientific collaborators of AOCS (http://www.aocstudy.org/), the project staff, and collaborating institutions; Maggie Angelakos, Judi Maskiell and Gillian Dite (ABCFS); RN Hanna Jantti for help with the patient data and the Finnish Cancer registry for the cancer data (HEBCS); Anne-Catherine Spiess and Georg Pfeiler (MUV); Betsy Bove, Mary Daly, John Malick, Beth Stearman, JoEllen Weaver (FCCC); Gisella Lombardi (PBCS); Beate Pesch, Volker Harth and Thomas Bruning for recruitment of GENICA study subjects and collection of epidemiological data.